Sertraline was approved in the following cases: depression, obsessive-compulsive disorder (OCD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder and social phobia (social anxiety).
Acute overdose is often shown vomiting, lethargy, ataxia, tachycardia and seizures. Plasma or serum concentration sertaline and norsertraline, its major active metabolite, may be measured to confirm the diagnosis of poisoning in hospitalized patients or to assist in the medicolegal deaths.
FDA requires all antidepressants, including sertraline, carry a black box warning that antidepressants may increase the risk of suicide in persons younger than 25 years. This warning is based on a statistical analysis conducted by two independent expert panels FDA, found that twice as many suicidal thoughts and behavior in children and adolescents, and 1.5 times more Suicidality in the 18-24 age group.
Corporate form of sertraline, Zoloft, was launched to consumers Pfizer, use the following wording: "At the time, for unknown reasons, depression may be associated with an imbalance of natural chemicals between nerve cells in the brain. Recipes Zoloft works to correct this imbalance. You just do not have feel this way again.
" An essay published in the journal PLoS Medicine noted that there is no scientific support for "an imbalance of serotonin, a" theory of depression, and criticized Pfizer and other manufacturers of SSRIs to use it. In response to a request for comment is a clear violation of federal regulations, FDA said that such a "simple declaration" was admissible to explain the neurochemistry of depression "that the percentage of the population that does not function above the sixth grade reading level.
"However, FDA quickly responded with a warning letter when Zoloft advertisement omitted risk information Suicidality.
